Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

INTERACTION OF CATECHOLAMINES WITH LEVORPHANOL AND MORPHINE IN THE MOUSE EYE

Alfred A. Smith, Meta Karmin and Jo Ann Gavitt
Journal of Pharmacology and Experimental Therapeutics January 1966, 151 (1) 103-109;
Alfred A. Smith
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Meta Karmin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jo Ann Gavitt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Reserpine has been found to block the formation of the transient lenticular opacities normally produced in mice by a large dose of levorphanol. Small doses of catecholamines, metaraminol or phenylephrine, but not amphetamine, serotonin, methacholine or histamine, restore the lenticular activity of this analgesic. These data suggest interaction of levorphanol and adrenergic substances to produce lenticular opacities. The interaction within the mouse eye was quantitatively studied by dropping concentrated solutions of epinephrine on the eye followed by intraperitoneal injection of levorphanol. The incidence of opacity rose in the treated eye with the higher concentrations of epinephrine. By varying the doses of the two drugs, a reciprocal relation between topical epinephrine and injected levorphanol was demonstrated. Mice quickly became tolerant to the lenticular effect of levorphanol, but simultaneous administration of norepinephrine failed to restore the full effect of the narcotic. Because uptake of labeled levorphanol into the lenses and brains of tolerant mice was found similar to that in the controls, it is suggested that tolerance to the lenticular action of levorphanol may actually represent insensitivity or tolerance to norepinephrine.

Footnotes

    • Accepted August 30, 1965.
  • The Williams & Wilkins Comapny

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 151, Issue 1
1 Jan 1966
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
INTERACTION OF CATECHOLAMINES WITH LEVORPHANOL AND MORPHINE IN THE MOUSE EYE
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

INTERACTION OF CATECHOLAMINES WITH LEVORPHANOL AND MORPHINE IN THE MOUSE EYE

Alfred A. Smith, Meta Karmin and Jo Ann Gavitt
Journal of Pharmacology and Experimental Therapeutics January 1, 1966, 151 (1) 103-109;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

INTERACTION OF CATECHOLAMINES WITH LEVORPHANOL AND MORPHINE IN THE MOUSE EYE

Alfred A. Smith, Meta Karmin and Jo Ann Gavitt
Journal of Pharmacology and Experimental Therapeutics January 1, 1966, 151 (1) 103-109;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • PST3093 Stimulates SERCA2a and Improves Cardiac Function
  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Pharmacological Characterization of Nicotine-Induced Seizures in Mice
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics