Abstract
It is possible to enhance the acute hyperbilirubinemic and cholestatic effects of α- naphthylisothiocyanate (ANIT) by pretreating mice with chlorpromazine or phenobarbital. The data strongly implicate the involvement of the endoplasmic reticulum in the ANIT-induced response for the following reasons: 1) Both chlorpromazine and phenobarbital stimulate hepatic microsomes. 2) The temporal aspects of the ANIT potentiation correlate well with the stimulatory effects of chlorpromazine and phenobarbital on barbiturate metabolism. 3) The potentiation can be blocked by the simultaneous administration of ethionine or actinomycin D. 4) The time course of the diphasic effects of SKF 525-A (β-diethylaminoethyl ethyl phenylpropylacetate HCl) on ANIT correlates well with the time course of the diphasic effect of SKF 525-A on barbiturate metabolism.
Footnotes
- Accepted June 25, 1965.
- The Williams & Wilkins Comapny
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POTENTIATION AND INHIBITION OF α-NAPHTHYLISOTHIOCYANATE-INDUCED HYPERBILIRUBINEMIA AND CHOLESTASIS
