Abstract
An improved assay method for inflammation in the rat’s foot is described. Bradykinin, histamine, serotonin, yeast and carrageenin were investigated. The kinetics of yeast-induced swelling were determined, and an equation was found that enables prediction of the swelling as a function of time and dosage. Similar work with carrageenin was done at a fixed dose. Evidence was obtained that for yeast inflammation, the mast cell may be involved, but for carrageenin inflammation no such clear evidence was found. Carrageenin can be blocked by soybean trypsin inhibitor, and therefore presumably acts through a proteolytic process. Bradykinin may be a mediator of this process.
Footnotes
- Accepted June 10, 1965.
- The Williams & Wilkins Comapny
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