Abstract
The site of acetylation of sulfanilamide and p-aminobenzoic acid in the rabbit has been examined utilizing isolated, intact hepatic parenchymal and reticuloendothelial cells and various other tissues. The acetylation of these compounds, usually attributed to the liver, was found to occur in cells of the reticuloendothelial system. No acetylation could be demonstrated in the hepatic parenchymal cells. Lung and spleen, organs known to contain a high percentage of reticuloendothelial cells, were also found to acetylate these compounds.
These findings emphasize the point that data obtained from experiments utilizing whole liver homogenates may not necessarily reflect a function of the hepatic parenchymal cells.
Footnotes
- Accepted May 26, 1965.
- The Williams & Wilkins Comapny
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.