Abstract
The actions of McN-A-343, pilocarpine and acetyl-β-methylcholine have been tested on synaptic transmission in isolated frog sympathetic ganglia. Individual ganglion cells were impaled with microelectrodes and stimulated both ortho- and antidromically. McN-A-343 (in concentrations >10-5 M) and piocarpine (in concentrations >2 x 10-4 M) depressed synaptic transmission. They did not depolarize or stimulate. Acetyl-β-methylcholine (in concentrations >10-4 M) also depressed synaptic transmission but in addition (in concentrations >10-3 M) depolarized and stimulated cells. The depolarization was transient but the depression of transmission persisted indefinitely in the presence of the drug. The stimulating action of acetyl-β-methylcholine was blocked by both hexamethonium and atropine.
Footnotes
- Accepted June 2, 1965.
- The Williams & Wilkins Comapny
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