Abstract
In my experiments pilocarpine hydrochloride in small doses 0.0005 to 0.05 per cent produced an increase in the tonus and tonus waves in less than 6 per cent of the experiments performed. These results are contrary to Fano and Bodano's findings. The difference is probably due to a difference in the strength of the solutions employed. The latter observers used 20 per cent solutions.
Atropine sulphate has no action on the tonus waves. These results confirm those of Bottazzi.
Adrenaline chloride decreased the increased tone set up by pilocarpine and simultaneously increased the height and rate of the contraction. In six other experiments performed, in which pilocarpine produced only a slowing of the heart rate and decreased the height of contraction, adrenaline antagonized the pilocarpine action.
Footnotes
- Received November 22, 1919.
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