Abstract
The effects of two antimetabolites of thiamine, pyrithiamine and oxythiamine, on the electrical activity of the nonmyelinated fibers in the desheathed rabbit vagus nerve have been examined. Pyrithiamine increased the amplitude of both the diphasic action potential recorded through external platinum electrodes and the monophasic action potential recorded in the sucrose-gap apparatus. In addition, pyrithiamine reversed the hyperpolarization produced in these fibers after a tetanus had been applied to the nerve. Oxythiamine, by contrast, was without effect. The difference in action of these two antimetabolites has been ascribed to differences in their transport; it has been shown here that oxythiamine does not penetrate into the particulate fraction of the nerve whereas pyrithiamine does. Other thiamine antimetabolites have been found ineffective in this preparation.
Footnotes
- Accepted January 8, 1965.
- The Williams & Wilkins Comapny
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