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Research ArticleArticle

BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY α-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE

S. Spector, A. Sjoerdsma and S. Udenfriend
Journal of Pharmacology and Experimental Therapeutics January 1965, 147 (1) 86-95;
S. Spector
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A. Sjoerdsma
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S. Udenfriend
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Abstract

Repeated administration of the tyrosine hydroxylase inhibitor, α-methyl-tyrosine to guinea pigs decreased catecholamine levels in brain stem, caudate nucleus, heart and spleen to undetectable levels. Serotonin was unaffected. That the catecholamine decrease was a consequence of inhibition of tyrosine hydroxylase was shown by the following: tissue concentrations of norepinephrine failed to rise following monoamine oxidase inhibition and decarboxylase inhibitors failed to block the α-methyl-tyrosine effect; the conversion of tyrosine-C14 to norepinephrine was inhibited whereas that from dopa-H3 was not; and there was a normal uptake of exogenous norepinephrine by heart and spleen in animals pretreated with α-methyl-tyrosine. Preliminary studies of the pharmacologic consequences of blockade of norepinephrine synthesis indicate impairment of motor activity and mild sedation in cats and guinea pigs and a reduction of the tyramine and norepinephrine pressor responses in guinea pigs and rats.

Footnotes

    • Accepted October 5, 1964.
  • The Williams & Wilkins Comapny

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Journal of Pharmacology and Experimental Therapeutics
Vol. 147, Issue 1
1 Jan 1965
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Research ArticleArticle

BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY α-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE

S. Spector, A. Sjoerdsma and S. Udenfriend
Journal of Pharmacology and Experimental Therapeutics January 1, 1965, 147 (1) 86-95;

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Research ArticleArticle

BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY α-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE

S. Spector, A. Sjoerdsma and S. Udenfriend
Journal of Pharmacology and Experimental Therapeutics January 1, 1965, 147 (1) 86-95;
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