Abstract
The sensory stimulating properties of a heterogeneous group of nicotinic and muscarinic drugs on the reflexogenic area in the region of the pulmonary artery bifurcation have been studied. Reflexogenic potency was assayed in the lightly a-chloralose anesthetized cat against lobeline utilizing the reflex hypotensive response. It was found that not all drugs that stimulate the ganglia, and only a few typically muscarinic drugs, have reflexogenic potency. The following were the most active compounds in decreasing order of potency-lobeline, acetylcholine, nicotine, choline phenyl ether, DMPP, metanicotine and 2 ,4-dimethylphenacyl tetramethylammonium. Tetramethylammonium and derivatives with a purely hydrocarbon side chain were inactive. Carbachol and mecholyl showed marked tachyphylaxis.
Footnotes
- Accepted August 21, 1964.
- The Williams & Wilkins Comapny
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