Abstract
The ability of histamine and other substances to counteract chlorpromazine-induced depression was observed as a reversal or prevention of the prostration and behavioral deficit following chlorpromazine injections. Histamine, reserpine and several antihistamines counteracted the depression while α-methyl-meta-tyrosine was ineffective. Pregnant mice and mice pretreated with the diamine oxidase inhibitor aminoguanidine, were resistant to chlorpromazine-induced depression. The data were interpreted as suggesting: 1. Depression induced by chlorpromazine may reflect in part some specific central antihistaminic activity not shared by the nonantipsychotic antihistamines. 2. Histamine has a role in the CNS, some parameters of which may be mediated through systems subserving overt manifestations of consciousness, awareness, arousal thresholds or motor co-ordination.
Footnotes
- Accepted July 24, 1964.
- The Williams & Wilkins Comapny
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