Abstract
Nethalide, a beta adrenergic inhibitor devoid of intrinsic sympathomimetic activity, has been demonstrated to possess antiarrhythmic properties when tested against ouabain or acetylstro-phanthidin-induced arrhythmias. Studies employing the acetylstrophanthidin titration procedure have shown that previous administration of nethalide alters the ability of the myocardium to develop automatic foci. Cardiac arrest or slow ventricular rhythms are more prominent after cardiotoxic doses of acetylstrophanthidin in the animal pretreated with nethalide.
That the antiarrhythmic action of nethalide cannot be explained entirely by its ability to produce beta adrenergic blockade has been demonstrated. Although this action may aid in producing antiarrhythmic effects, particularly in adrenergically-induced arrhythmias, it is suggested that nethalide possesses an additional pharmacologic effect to account for its antiarrhythmic action.
Footnotes
- Accepted May 11, 1964.
- The Williams & Wilkins Comapny
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|