Abstract
The penetration of 2-PAM-C14 into selected regions of rat brain has been measured. Treatment with toxic doses of the alkylphosphate cholinesterase inhibitor Dipterex increased the concentration of 2-PAM-C14 in four of the eight brain regions analyzed. Other cholinesterase inhibitors, hypercapnia and convulsions did not produce a similar increase in the concentration of 2-PAM-C14 in brain. The experimental data suggest that 2-PAM is actively transported by brain in vitro, and that Dipterex inhibits this transport. It has been Proposed that 2-PAM may be transported out of brain in vivo.
Footnotes
- Accepted April 8, 1964.
- The Williams & Wilkins Comapny
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