Abstract
Administration of N-isopropyl methoxamine (IMA) lowered markedly the fasting plasma free fatty acids (FFA) of the conscious dog and man. Comparative experiments with the D- and L- isomers of the drug showed that this activity resides in the L- form. IMA blocked the marked elevation of plasma FFA and triglycerides which occurs in the dog exposed to a cold environment. The cold-induced rise of circulating FFA was blocked with difficulty in the rat presumably because this species metabolizes the drug at a much more rapid rate than the dog. Man and dog metabolize IMA at about the same rate with a biological half-life of about 6 hours. Since IMA has been shown to exert a potent effect in blocking the catecholamine-induced release of FFA, the results presented here provide additional evidence for the requirement of the sympathetic nervous system in the mobilization of FFA.
Footnotes
- Received October 18, 1963.
- Accepted December 18, 1963.
- The Williams & Wilkins Company
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$35.00
Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.
In this issue
INHIBITION OF LIPID MOBILIZATION BY N-ISOPROPYL METHOXAMINE (B.W. 61-43)
