Abstract
The effects of two antihypertensive agents, guanethidine and reserpine, were evaluated on the microcirculation by direct microscopic studies of rat mesoappendix vasculature. The administration of guanethidine (7.5 mg/kg) was found to produce a 3-fold sensitization to topically applied epinephrine within 10 minutes. Sensitization to topical epinephrine was recorded 30 minutes after the administration of reserpine (1.0 mg/kg). The chronic administration of both drugs produced a pattern of sensitization very similar to that of topically applied epinephrine.
The increased reactivity of the peripheral vascular bed (rat mesocecum), following treatment with reserpine and guanethidine, is discussed in relation to the effects of reserpine and guanethidine on the heart and other tissues.
Footnotes
- Received December 31, 1962.
- Accepted July 11, 1963.
- The Williams & Wilkins Company
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