Abstract
Indomethacin, 1-(p-chlorobenzoyl) - 5 methoxy-2-methylindole-3-acetic acid, is a potent anti-inflammatory and antipyretic compound. It is orally active as an inhibitor of cotton pellet granuloma formation in the rat, with a potency about 85 times that of phenylbutazone and about 4 times that of hydrocortisone. It is equally active in intact or adrenalectomized rats and is effective when applied directly to the cotton pellet. When used in conjunction with a steroid, the action of the latter is enhanced. Indomethacin is also a potent inhibitor of edema induced in the rat's foot by subplantar injection of carrageenin. The compound is an active antipyretic drug, with potency 10 to 20 times that of phenylbutazone.
Footnotes
- Received February 27, 1963.
- Accepted May 21, 1963.
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