Abstract
The rate of removal of radioiodide injected into the myocardium of dogs was influenced by changes in the coronary circulation. In patients with coronary artery disease the disappearance of radioiodide from the myocardium was variable with the T½ ranging from 0.8 to 13.5 minutes. Although radioiodide removal from some areas of the heart muscle was slow at rest, it increased during exercise. The absence of an increase in radioiodide removal following the administration of nitrites was associated with reductions of blood pressure caused by these drugs.
The findings suggest that: 1) the rate of disappearance of radioiodide injected into the myocardium is an index of local myocardial blood flow; 2) myocardial blood flow in patients with coronary artery disease is reduced in some areas of the heart but is capable of increasing, and 3) the failure of nitroglycerine to increase myocardial blood flow may be due in part to the concomitant reductions in blood pressure caused by the drug.
Footnotes
- Received June 22, 1962.
- Accepted September 5, 1962.
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