Abstract
The effects of β-phenylisopropylhydrazine (PIH) and iproniazid on spontaneous and forced motor activity were investigated in male, albino, Swiss-Webster mice. There was a marked difference in the effects of PIH and iproniazid on spontaneous motor activity in that PIH produced potent stimulatory effects whereas iproniazid greatly depressed spontaneous activity. Both compounds decreased "rotarod" performance time. The ataxia and hindlimb weakness produced by chronic administration of PIH to rats and dogs appears to be due to a depression of spinal polysynaptic pathways.
Footnotes
- Received May 5, 1962.
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