Abstract
The analgetic activity of prodilidine hydrochloride (1,2-dimethyl-3-phenyl-3-pyrrolidyl propionate hydrochloride) was demonstrated in the rat, mouse and dog in tests using noxious thermal, mechanical, chemical, and electrical stimuli. Analgetic potency was generally equivalent to that of codeine sulfate.
Prodilidine HCl was unable to suppress withdrawal phenomena in morphine-dependent monkeys.
Prodilidine HCl had no respiratory depressant, antipyretic, hypothermic, or antitussive activity at analgetic levels. However, it did produce an early potentiation and late reduction of pentobarbital anesthesia in mice. The crossed extensor reflex was augmented in the spinal cat. Cardiovascular and gastrointestinal studies indicated no deleterious effects at therapeutic levels.
Footnotes
- Received May 12, 1961.
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