Abstract
The contentand distribution of various analgetic drugs have been determined in the brains of mice, rats, cats, dogs and monkeys at several times after administration. No significant localization of salicylates or of N-acetyl-p-aminophenol has been detected in any portion of the brain. In all species studied, the pituitary glands show a 2-to 3-fold greater concentration than is found in the brain throughout the time period studied. Acetylsalicylate administration to animals leads to the recovery in brain of free salicylate only, in concentrations corresponding to those after salicylate administration. N-acetyl p-aminophenol and salicylamide penetrate the brain to a somewhat greater extent than does the salicylate ion.
Footnotes
- Received April 10, 1961.
- © 1961, by The Williams & Wilkins Company
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.