Abstract
The effects of reserpine and cold-exposure have been compared on various indices of pituitary adrenal stimulation in rats: adrenal ascorbic acid, plasma corticosterone and FFA, and liver TPO. Both reserpineand cold-exposure elicita marked hypersecretion of ACTH. Of a number of Rauwolfia alkaloids, however, only those compounds which lowered brain stores of norepinephrine and serotonin and produced sedation, also evoked ACTH hypersecretion. A large dose of reserpine or a prolonged cold-exposure decreased the content of ACTH in the pituitary to suchan extent that the animals could not respond to an additional pituitary stimulus.
Footnotes
- Received May 1, 1961.
- © 1961, by The Williams & Wilkins Company
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