Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

ACCUMULATION OF EPINEPHRINE AND NOREPINEPHRINE BY SOME RAT TISSUES

B. C. R. STR\l=O"\MBLAD and MARK NICKERSON
Journal of Pharmacology and Experimental Therapeutics November 1961, 134 (2) 154-159;
B. C. R. STR\l=O"\MBLAD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
MARK NICKERSON
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Tissue handling of catecholamines has been investigated on the basis of determinations of tissue levels in rat hearts and salivary glands. Bilateral suprarenal demedullation did not alter the tissue levels. Chronic superior cervical gan glionectomy led to the disappearance of norepinephrime but not of epinephrine from the salivary glands. Combining these two procedures resulted in disappearance of both amimes.

Injection of epinephrine or norepinephrine into demedullated animals caused a marked increase in the content of the corresponding amine in the heart and salivary glands and a decrease in the concentration of the other, indicating decreased synthesis, or more probably, displacement of endogenous catecholamine. Most of the increase in salivary glands following injection was prevented by chronic superior cervical ganglionectomy, which limited the catecholamine content to the equivalent of the epinephrine level in denervated glands from animals with intact suprarenals.

It is concluded that epinephrine and norepinephrine can be accumulated from the bloodstream and stored in tissues other than those in which they were synthesized. Most of the accumulation is in tissue sympathetic nerve endings, which have a storage capacity considerably greater than their normal catecholamine content. Quantitative aspects of this uptake suggest that it may play an important role in terminating the actions of exogenous and particularly those of endogenous catecholamines.

Footnotes

    • Received April 17, 1961.
  • © 1961, by The Williams & Wilkins Company

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 134, Issue 2
1 Nov 1961
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
ACCUMULATION OF EPINEPHRINE AND NOREPINEPHRINE BY SOME RAT TISSUES
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

ACCUMULATION OF EPINEPHRINE AND NOREPINEPHRINE BY SOME RAT TISSUES

B. C. R. STR\l=O"\MBLAD and MARK NICKERSON
Journal of Pharmacology and Experimental Therapeutics November 1, 1961, 134 (2) 154-159;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

ACCUMULATION OF EPINEPHRINE AND NOREPINEPHRINE BY SOME RAT TISSUES

B. C. R. STR\l=O"\MBLAD and MARK NICKERSON
Journal of Pharmacology and Experimental Therapeutics November 1, 1961, 134 (2) 154-159;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Mechanisms of 5-Hydroxytryptamine2A Receptor Activation of the Mitogen-Activated Protein Kinase Pathway in Vascular Smooth Muscle
  • Interactive Role for Neurosteroids in Ethanol Enhancement of γ-Aminobutyric Acid-Gated Currents from Dissociated Substantia Nigra Reticulata Neurons
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics