Abstract

Su-8629 (2-amino-indane) has oral analgesic potency and a therapeutic index comparable to morphine sulfate; it is unlike morphine in that it does not depress respiration and is not antagonized by nalorphine.

In addition to its intrinsic analgesic effects, Su-8629, given in subthreshold doses, potentiates the analgesic effects of morphine, a property which it has in common with amphetamine. Su-8629, amphetamine and morphuine all afford protection against writhing induced by the intraperitoneal administration of acetic acid.

The very marked increase in toxicity of amphetamine fouml in crowded mice as compared to isolated ones is not seen with Su-8629, nor does Su-8629 increase spontaneous motor activity as amphetamine does. On the other hand, Su-8629 and amphetamine, but not morphine, cause some elevation in electroshock threshold.

Su-8629, amphetamine and morphine, when given in appropriate doses, reduce gastrointestinal motility of the mouse.

Whereas morphine depresses respiration, blood pressure and spinal reflexes of intact chloraloseurethane anesthetized cats, Su-8629 and amphetamine in sufficiently high doses increase respiration, blood pressure and spinal reflexes.

Su-8629 does not alter the blood sugar of the unanesthetized rabbit.