Abstract
Pretreatment of rats with chlorcyclizine for several days shortens the duration of action of a subsequent dose of hexobarbital, pentobarbital or zoxazolamine by increasing the activity of the liver microsomal enzymes that metabolize these drugs. Accelerated in vivo metabolism of hexobarbital was observed in chlorcyclizine-treated rats. Although pretreatment of rats with chlorcyclizine, barbital, phenobarbital or orphenadrine shortens the duration of action of hexobarbital, the duration of action of barbital was not significantly shortened. Pretreatment of rats with chlorcyclizine also increases the activity of enzyme systems in liver microsomes that N-demethylate 3 - methyl - 4 - monomethylamino-azobenzene and that metabolize reduced TPN. Removal of the pituitary gland, adrenal glands or testis did not prevent accelerated barbiturate metabolism by liver microsomes when chlorcyclizine or phenobarbital was administered.
Footnotes
- Received October 6, 1960.
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