Abstract
Neuromuscular blockade following poisoning of the rat with DFP is shown to be rapidly antagonized by TMB-4 in vitro and in vivo. Concurrent study of the ChE activity following the addition of TMB-4 in vitro shows significant recovery of ChE activity of intact muscle after 10 minutes under the conditions used. Comparable results were obtained following TMB-4 treatment of sarin-poisoned rats.
No reactivation of brain ChE activity was found following TMB-4 treatment, consistent with the apparent inability of quaternary compounds to penetrate the blood-brain barrier, and the potentiating action of atropine in promoting the chemotherapeutic effectiveness of TMB-4 shown previously.
Footnotes
- Received April 28, 1960.
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