Abstract
Slow intravenous infusions of serotonin produced in dogs, premedicated with reserpine, very marked hypotension and bradycardia as well as characteristic depression. Without reserpine premedication, serotonin had no effect.
Similar results were obtained by infusion of 5-hydroxytryptophane and .1-benzyl-2,5-di-methylserotonin.
Rapid intravenous injection of 5-hydroxytryptophane caused a characteristic central stimulation in normal dogs and severe depression in dogs pretreated with reserpine.
The implications of these observations are discussed.
Footnotes
- Received May 13, 1960.
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