Abstract
Bufotenine and psilocybin both possess vasopressor activity in anesthetized rats which is similar to serotonin and which can be blocked by BOL. The duration of pressor action is, however, greater, namely 30 minutes, with bufotenine and more than 1 hour with psilocybin.
The duration of pressor activity is proportional and probably related to the rate at which these compounds are inactivated by monoamine oxidase in the in vitro experiments.
Experiments in vivo confirm that bufotenine and psilocybin are much less readily destroyed by monoamine oxidase than is serotonin; and that the alternative pathways of metabolism, namely excretion unchanged, or in conjugation with glucuronic acid are of more importance.
The potentiation of hexobarbital sleeping times indicates that cardiovascular effects are paralleled by a central effect. The potentiation was 58%, 75% and 126% for serotonin, bufotenine and psilocybin, respectively.
Unusual toxic effects characterized by weight loss and spinal kyphosis were found to occur 7 to 10 days after doses of 125 and 100 mg/kg of bufotenine and psilocybin, respectively.
Footnotes
- Received February 9, 1960.
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THE RELATIONSHIP BETWEEN THE METABOLIC FATE AND PHARMACOLOGICAL ACTIONS OF SEROTONIN, BUFOTENINE AND PSILOCYBIN
