Abstract
Chlorpromazine has been characterized with rabbit aortic strips as a slowly reversible adrenergic blocking agent.
Chlorpromazine increased the magnitude and markedly prolonged the pressor response to levarterenol while depressing the magnitude of the response to l-epinephrine.
Chlorpromazine sulfoxide enhanced the magnitude and prolonged the duration of the levarterenol-induced blood pressure rises and tachycardia; it prolonged the duration of l-epinephrineevoked tachycardia and pressor responses,
It has been proposed that chiorpromazine has two dissociable actions on epinephrine and levarterenol. It (1) blocks the adrenergic receptor and (2) depresses some deactivating process.
Chlorpromazine did not significantly alter the uptake of either l-epinephrine or levarterenol by the red blood cell; it did not significantly alter inactivation of these amines by liver slices.
Footnotes
- Received January 2, 1960.
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