Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

THE CARDIOSTIMULANT ACTION OF CERTAIN GANGLIONIC STIMULANTS ON THE EMBRYONIC CHICK HEART

Woo Choo LEE, Leslie P. McCarty, Warren W. Zodrow and F. E. Shideman
Journal of Pharmacology and Experimental Therapeutics September 1960, 130 (1) 30-36;
Woo Choo LEE
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Leslie P. McCarty
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Warren W. Zodrow
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
F. E. Shideman
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Nicotine exhibits marked positive inotropic activity at a concentration of 2 x 10-5 g/ml, or greater on the noninnervated heart of the 4-day-old chick embryo. There usually is observed an initial transient positive chronotropic effect which is followed by a decrease in heart rate. Higher concentrations of nicotine produce more pronounced negative chronotropic effects. Innervation does not significantly alter the cardiostimulant responses to nicotine. Essentially similar positive inotropic and chronotropic effects are produced by tetramethylammonium iodide (10-4 g/ml) and acetylcholine chloride (10-4 g/ml) on the atropinized embryonic heart.

Dichioroisoproterenol, which blocks the effects of epinephrine on the heart of the 4-day-old chick embryo, abolishes the cardiostimulant responses to nicotine but not those to barium chloride or ouabain. A congener of choline 2:6-xylyl ether, trimethyl (2-(2,6-xylyloxy)propyll ammonium chloride, which interferes with release and/or synthesis of the adrenergic mediator, blocks the cardiac responses to nicotine but not to epinephrine. Reserpine markedly reduces the catecholamine concentration of the 15-day-old embryonic heart and significantly decreases the positive inotropic response to nicotine by the heart of the 5-day-old embryo. Significant amounts of catecholamines, as demonstrated by spectrophotofluorometric methods, are present in the 4-day-old embryonic chick heart.

It may be concluded from the data presented that the positive inotropic and chronotropic effects of nicotine and certain other ganglionic stimulants are not dependent on the presence of sympathetic nerve endings in the heart. The evidence further suggests that there exist between the postganglionic sympathetic nerve endings and the adrenergic receptors in the heart certain structures which contain epinephrine-like material(s). Nicotine and similar agents cause a release of this material which in turn effects the positive inotropic and chronotropic responses.

Footnotes

    • Received January 14, 1960.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 130, Issue 1
1 Sep 1960
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
THE CARDIOSTIMULANT ACTION OF CERTAIN GANGLIONIC STIMULANTS ON THE EMBRYONIC CHICK HEART
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

THE CARDIOSTIMULANT ACTION OF CERTAIN GANGLIONIC STIMULANTS ON THE EMBRYONIC CHICK HEART

Woo Choo LEE, Leslie P. McCarty, Warren W. Zodrow and F. E. Shideman
Journal of Pharmacology and Experimental Therapeutics September 1, 1960, 130 (1) 30-36;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Research ArticleArticle

THE CARDIOSTIMULANT ACTION OF CERTAIN GANGLIONIC STIMULANTS ON THE EMBRYONIC CHICK HEART

Woo Choo LEE, Leslie P. McCarty, Warren W. Zodrow and F. E. Shideman
Journal of Pharmacology and Experimental Therapeutics September 1, 1960, 130 (1) 30-36;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Interaction of Diclofenac and Quinidine in Monkeys: Stimulation of Diclofenac Metabolism
  • Discriminative Stimulus Effects of Zolpidem in Squirrel Monkeys: Comparison with Conventional Benzodiazepines and Sedative-Hypnotics
Show more Article

Similar Articles

  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics