Abstract
The renal tubular excretion of N1-methylnicotinamide (NMN) was inhibited by mecamylamine, quinine, quinidine and quinacrine when the inhibitors and NMN were infused simultaneously into the portal circulation of one kidney in the chicken.
Quinine also inhibited the tubular excretion of tetraethylammonium.
The rates of excretion of quinine and mecamylamine themselves were of a low order of magnitude even though the urine was acid.
The possibility of a relationship between the tubular excretion of mecamylamine and certain other amines in the mammalian kidney, which has been regarded as a passive non-ionic diffusion process, and the tubular excretion of NMN, which is believed to be based on active transport, is discussed.
Footnotes
- Received December 3, 1959.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.