Abstract

The absorption of pentobarbital sodium from the urinary bladders of unanesthetized, catheterized adult, male, mongrel dogs has been demonstrated.

The physiological changes taken as an indication that the drug was being absorbed consisted of depression of respiration, ataxia, and the loss of the corneal reflex.

Bladder absorption of pentobarbital sodium appears to be dependent upon the state of the bladder mucosa, the extent of bladder distention, and the concentration of the solution employed.