Abstract
A main reaction of nicotine metabolism in rabbit appears to be hydroxylation in the alpha position of the pyrrolidine ring to form a hydroxynicotine. This oxidation occurs in liver microsomes and requires TPNH and O2; the product has the properties of a cyclized amino aldehyde. The hydroxynicotine then undergoes oxidation to cotinine, a reaction that may be catalyzed by an aldehyde oxidase.
Footnotes
- Received October 19, 1959.
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