Abstract
In dogs, cardiac potassium balance was not altered by elevation of heart rate in 27 heartlungs and 4 open-chest preparations, under pentobarbital anesthesia or after cyclopropane anesthesia.
Additional pentobarbital (45 to 180 mg) caused cardiac failure but did not affect cardiac potassium balance. Acceleration of heart rate now caused loss of potassium from the heart.
Dihydro-ouabain (300 µg) reversed the failure produced by pentobarbital and caused potassium loss from the heart beating at normal rate. Acceleratioll of heart rate now caused the same potassium loss seen with pentobarbital failure.
Footnotes
- Received October 26, 1959.
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