Abstract
2,6-Dimethyl- and 2,6-dichlorophenoxyethyl trimethylammonium bromides, together with their alpha and beta methyl analogs were synthesized and studied for autonomic effects.
Muscarinic stimulant activity of the unsubstituted compounds was reduced by alpha methylation and eliminated by beta methylation.
Sympathetic inhibitor potency, revealed by relaxation of the nictitating membrane in unanesthetized cats, was reduced by alpha methylation.
Tests with autonomic drugs and nerve action potential recordings indicated that the characteristic inhibition produced by the unsubstituted and the beta-substituted congeners is selective for the terminal sympathetic nerve endings.
Footnotes
- Received October 10, 1959.
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