Abstract
Acetyl digitoxin, like digitoxin, has been shown to be excreted only slowly by rats. About 5% of the dose was present in the urine after 12 hours, and 9% in the bile after 6 hours.
The urine contained acetyl digitoxin, digitoxin, 12-hydroxy digitoxin (digoxin) and digoxin metabolite B. The bile contained acetyl digitoxin and digoxin. Metabolites of acetyl digitoxin were also detected in the blood, liver, heart and kidneys of rats.
Footnotes
- Received September 10, 1959.
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THE METABOLISM OF ACETYL DIGITOXIN IN THE RAT
