Abstract
An in vitro screening technique showed several anion exchange resins were capable of removing barbiturates from normal human serum. Dowex 1-X4 was the most effective by this technique.
An apparatus using an ion exchange resin was designed, constructed and tested. This resin column apparatus was used successfully in the resuscitation of dogs acutely poisoned with phenobarbital sodium. The principle used is new in the treatment of barbiturate intoxication. The resin column apparatus is simple in construction, of small size and efficient.
Preliminary toxicity studies showed that there is little change in the physiological electrolyte balance following use of the ion exchange resin column. There is a considerable reduction in white blood cells and thrombocytes. The white blood cell removal appears to be no problem since recovery to normal levels is speedy and uniform. The thrombocyte loss, however, presents the additional problem that the recovery may be delayed. A precipitous fall of platelets may be prevented by gentle manipulation of the resin column during the saline rinse of the resin beads.
The important advantages and disadvantages of this new form of treatment are discussed.
Footnotes
- Received August 21, 1959.
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THE USE OF ION EXCHANGE RESINS IN THE TREATMENT OF PHENOBARBITAL INTOXICATION IN DOGS
