Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

SOME PHARMACOLOGICAL ACTIONS OF BETA A-PHENYLISOPROPYLHYDRAZINE (PIH)

L. G. Eltherington and A. Horita
Journal of Pharmacology and Experimental Therapeutics January 1960, 128 (1) 7-14;
L. G. Eltherington
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Horita
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Beta-phenylisopropylhydrazine (JB-516, PIH, Catron) produces a variety of pharmacological actions due to inhibition of monoamine oxidase (MAO) and because of its structural similarity to amphetamine. A comparison with some actions of another MAO inhibitor, 1-isonicotinyl-2-isopropylhydrazine (iproniazid, Marsilid) has been made.

Injection of single lethal and sublethal doses of PIH in conscious animals produced behavioral changes and signs of autonomic nervous system stimulation.

The mean arterial pressure of anesthetized dogs was raised by closes of PIH from 0.05 to 5 mg/kg. This rise in pressure was blocked by Dibenzyline but not altered by BOL-148 or TEA. PIH and amphetamine exhibited cross tachyphylaxis.

In anesthetized dogs, PIH pretreatment causes a reversal of the usual depressor response of reserpine. This "reserpine reversal" was blocked by Dibenzyhine but unaffected by BOL-148 or TEA.

PIH, in doses of from 0.25 to 5 mg/kg, produced an attenuation of the carotid sinus reflex (CSR) elicited by compression of both common carotid arteries of anesthetized dogs.

Mice injected with reserpine at various time intervals after PIH showed intense sympathetic stimulation instead of the usual sedation typical of reserpine administered alone. This effect of PIH is correlated with inhibition of brain MAO. Iproniazid was considerably less effective.

Hexobarbital sleep in mice pretreated with PIH was prolonged. Iproniazid, in a dose which produces 100% inhibition of MAO in brain and liver, was much more effective in prolonging hexobarbital sleep than a dose of PIH which yields maximum inhibition of brain and liver MAO.

Footnotes

    • Received July 15, 1959.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 128, Issue 1
1 Jan 1960
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
SOME PHARMACOLOGICAL ACTIONS OF BETA A-PHENYLISOPROPYLHYDRAZINE (PIH)
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

SOME PHARMACOLOGICAL ACTIONS OF BETA A-PHENYLISOPROPYLHYDRAZINE (PIH)

L. G. Eltherington and A. Horita
Journal of Pharmacology and Experimental Therapeutics January 1, 1960, 128 (1) 7-14;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

SOME PHARMACOLOGICAL ACTIONS OF BETA A-PHENYLISOPROPYLHYDRAZINE (PIH)

L. G. Eltherington and A. Horita
Journal of Pharmacology and Experimental Therapeutics January 1, 1960, 128 (1) 7-14;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Tissue Selectivity of Antidiabetic Agent Nateglinide: Study on Cardiovascular and β-Cell KATP Channels
  • Distribution in Rat Brain of Binding Sites of Kaliotoxin, a Blocker of Kv1.1 and Kv1.3 α-Subunits
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics