Abstract
Studies in rabbits of the disappearance of various drugs introduced into the CSF indicate that the substances pass the boundary from CSF to blood stream by a route which differs from the blood-CSF barrier, in that it permits the ready passage of poorly lipid-soluble substances. The relatively rapid disappearance of polar substances from the CSF, presumably through the arachnoid villi, may explain why drugs that slowly enter the CSF from the blood stream fail to attain a CSF/plasma distribution ratio of 1.0.
Footnotes
- Received July 6, 1959.
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