Abstract
A system metabolizing strychnine has been found in the livers of several animal species. Intracellular distribution studies showed the transformation to be occurring in the microsomes with the soluble fraction supplying the cofactor. Maximal metabolism required reduced TPN, oxygen, a pH of 8.4 and a high concentration of strychnine. Evidence for the enzymic nature of the system was presented.
Metabolism as measured by loss of methyl orange-reacting material correlated well with loss of the biological activity of strychnine as determined in mice.
The nature of the metabolite or metabolites formed is unknown.
Footnotes
- Received April 13, 1959.
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ENZYMATIC METABOLISM OF STRYCHNINE
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