Abstract
The technique of "stop-flow" analysis has been used to compare proximal and distal tubular function in dogs before and after administration of chlorothiazide.
After chlorothiazide the ability of the proximal tubule to reabsorb water during stopped flow was reduced. Proximal reabsorption of sodium and potassium was reduced in such amounts that the concentrations of these substances in the fluid reabsorbed from the proximal tubule during occlusion did not change but remained plasma-like.
Chlorothiazide increased distal tubular potassium secretion. TIme data on distal potassium reabsorption are less clear-cut, but chlorothiazide does appear to have some inhibitory effect upon distal potassium reabsorption. Chlorothiazide exerted no effect on the distal capacity to lower sodium concentration during stopped flow.
Footnotes
- Received July 12, 1958.
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