Abstract
In vitro antihistamine studies on guinea pig gut have demonstrated that d-chlorpheniramine was approximately twice as potent as the racemic compound. The l-isomer had only about one-one hundredth the potency of dl-chlorpheniramine.
The oral protective action of the d-isomer against death induced by intravenous or aerosolized histamine in guinea pigs revealed an average potency of 1.8-2.4 times that observed for the racemic compound.
The general pharmacodynamics of the d-isomer in the anesthetized dog were similar to those of the dl-compound.
The central nervous system effect of all 3 drugs in mice and cats was manifested as general stimulation of approximately the same degree.
The acute toxicity of the d-isomer in guinea pigs, rats and mice was no greater than that of the dl-compound.
Oral subacute studies in the rat and monkey did not reveal any abnormalities which could be attributed to administration of either d-or dl-chlorpheniramine.
Footnotes
- Received July 28, 1958.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
