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Research ArticleArticle

THE COMPARATIVE DISTRIBUTION OF C14-LABELED 2-DIMETHYLAMINOETHANOL AND CHOLINE IN THE MOUSE

D. P. Groth, J. A. Bain and C. C. Pfeiffer
Journal of Pharmacology and Experimental Therapeutics December 1958, 124 (4) 290-295;
D. P. Groth
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J. A. Bain
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C. C. Pfeiffer
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Abstract

The time course distribution of radioactivity from dimethylaminoethanol-1,2 C14, cholinemethyl -C14 and choline-1,2 C14 in the acidsoluble, lipid, and protein fractions of mouse brain and liver was determined following the intraperitoneal injection of from 0.1 to 150 mg/kg of the labeled compounds. Incorporated radioactivity into choline and choline derivatives of the acid-soluble and lipid extracts was determined by carrier technique. Incorporation of radioactivity into protein methionine was also followed. Dimethylaminoethanol was incorporated and retained by the brain to a greater extent than choline, although choline was a more effective immediate precursor of acidsoluble and lipid choline. Label from choline appeared in the respiratory carbon dioxide and was excreted in the urine at a higher rate than the label from dimethylaminoethanol. The relative efficacy of dimethylaminoethanol and choline as precursors of brain acid-soluble and lipid choline and the implication of the results obtained to the pharmacological properties of dimethylaminoethanol was discussed.

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    • Received July 28, 1958.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 124, Issue 4
1 Dec 1958
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Research ArticleArticle

THE COMPARATIVE DISTRIBUTION OF C14-LABELED 2-DIMETHYLAMINOETHANOL AND CHOLINE IN THE MOUSE

D. P. Groth, J. A. Bain and C. C. Pfeiffer
Journal of Pharmacology and Experimental Therapeutics December 1, 1958, 124 (4) 290-295;

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Research ArticleArticle

THE COMPARATIVE DISTRIBUTION OF C14-LABELED 2-DIMETHYLAMINOETHANOL AND CHOLINE IN THE MOUSE

D. P. Groth, J. A. Bain and C. C. Pfeiffer
Journal of Pharmacology and Experimental Therapeutics December 1, 1958, 124 (4) 290-295;
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