Abstract
The effects of reserpine and hydralazine on carotid presso- and chemoreceptor activity, on efferent splanchnic nerve activity and on arterial pressure were studied on normotensive, anesthetized cats, immobilized by decamethonium.
Reserpine, administered by close intracarotid injection, induced a gradually appearing, moderate, prolonged activation of chemoreceptors. An early transient depression of pressoreceptors was shown to be due to the vehicle employed. Hypotensive doses of reserpine administered intravenously reduced in large doses, but never abolished, spontaneous and reflexly evoked splanchnic nerve activity.
Hydralazine increased chemoreceptor activity after both close arterial and intravenous administration. Splanchnic activity was unaffected by hypotensive doses of this agent. It is concluded that reserpine can partially inhibit vasoconstrictor outflow through the splanchnic nerves. Hydralazine has no similar action and behaves like a slowly acting peripheral vasodilator.
Footnotes
- Received February 2, 1957.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
