Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

SOME FACTORS AFFECTING THE BIOLOGICAL DISPOSITION OF SMALL DOSES OF MORPHINE IN RATS

T. K. Adler, H. W. Elliott and R. George
Journal of Pharmacology and Experimental Therapeutics August 1957, 120 (4) 475-487;
T. K. Adler
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
H. W. Elliott
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R. George
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The metabolic fate of small doses of C14-labeled morphine in rats as influenced by adrenalectomy or pretreatment with ACTH or vasopressin has been studied utilizing isotope dilution and paper chromatography techniques. The principal findings were as follows:

The ratio of bound to free morphine is 2 to 3 times greater in the urine and plasma of Sprague-Dawley rats than in Long-Evans rats on the same dose.

The C14 content of plasma can be almost completely accounted for as free and bound morphine but a substantial fraction of that present in brain and muscle remains unidentified as does a very small fraction in urine of Long-Evans rats.

The tissues of adrenalectomized rats, of both strains, contain higher concentrations of C14 after morphine-N-C14H3 administration than do control rats. Plasma bound morphine levels indicate no impairment in the ability of these animals to conjugate morphine.

Although vasopressin increases the sensitivity of rats to morphine, tissue concentrations after pretreatment with vasopressin are either reduced or relatively unaffected in marked contrast to the increased values after adrenalectomy.

Tissue C14 levels after ACTH are similar to those after vasopressin. Thus decreased sensitivity to morphine due to ACTH is not reflected in lower brain C14 concentrations.

None of the treatments appear to affect the absorption of the dose or urinary excretion at sixty minutes after injection.

Footnotes

    • Received March 25, 1957.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 120, Issue 4
1 Aug 1957
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
SOME FACTORS AFFECTING THE BIOLOGICAL DISPOSITION OF SMALL DOSES OF MORPHINE IN RATS
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

SOME FACTORS AFFECTING THE BIOLOGICAL DISPOSITION OF SMALL DOSES OF MORPHINE IN RATS

T. K. Adler, H. W. Elliott and R. George
Journal of Pharmacology and Experimental Therapeutics August 1, 1957, 120 (4) 475-487;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

SOME FACTORS AFFECTING THE BIOLOGICAL DISPOSITION OF SMALL DOSES OF MORPHINE IN RATS

T. K. Adler, H. W. Elliott and R. George
Journal of Pharmacology and Experimental Therapeutics August 1, 1957, 120 (4) 475-487;
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • PST3093 Stimulates SERCA2a and Improves Cardiac Function
  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Modulation by Drugs of Human Hepatic Sodium-Dependent Bile Acid Transporter (Sodium Taurocholate Cotransporting Polypeptide) Activity
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics