Abstract
A study has been made of the effects of pH of the superfusate and atropine concentration on the responses of the superfused rat uterus and the guinea pig ileum to 5-hydroxytryptamine and acetylcholine. The rat uterus is more sensitive to 5-hydroxytryptamine and acetylcholine than the guinea pig ileum. It is possible to estimate the amount of 5-hydroxytryptamine in the presence of acetylcholine by the selection of a concentration of atropine which blocks the latter and only slightly diminishes the responses to the former. It has been shown that a more acid pH decreases the sensitivity of the rat uterus to both acetyicholine and 5-hydroxytryptamine and increases its sensitivity to atropine.
Footnotes
- Received March 2, 1957.
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