Abstract
When patients with focal brain damage and epilepsy are given primidone or phenobarbital at eight-hour intervals for three days, it is possible to determine the relative anticonvulsant activity of these agents. A study of this sort, involving twenty patients who received all medications, indicates that 250 mgm. of primidone and 50 mgm. of phenobarbital are approximately equivalent. When these two drugs are given together an additive and not a potentiated effect is observed.
Footnotes
- Received December 31, 1956.
- © 1957 by The Williams & Wilkins Co.
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