Abstract
Five segments excised from different parts of the rabbit's intestine have been studied under identioal conditions in warm aerated Locke's solution. Seventy-six substances were tested. Some affected all the segments about equally, while others affected them unequally and even dissimilarly. A number produced effects more or less graded from one end of the tract to the other. It is suggestive that a number of the drugs which through their graded actions might tend to steepen the intestinal gradient are used as laxatives, and a number of those which might tend to reverse the gradient are well-known emetics.
Some of the drugs affected the colon particularly. Others had a peculiarly depressant effect on the jejunum.
A list of convenient dosages is appended.
Footnotes
- Received August 28, 1918.
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