Abstract
The elimination of free morphine from the blood of non-tolerant mats follows a first order reaction. In tolerant rats, free morphine is eliminated more rapidly from the blood and the rate does not follow a first order reaction. More bound morphine appears in the blood of tolerant than in non-tolerant rats 60 minutes after the injection.
There is less free morphine in the brains of tolerant rats than in non-tolerant animals, one and three hours after the injection of 75 mgm./kgm. of morphine. This difference however, does not explain tolerance.
Neostigmine, although potentiating the effect of morphine, does not increase the concentration of morphine in blood and brain tissue.
Footnotes
- Received July 2, 1956.
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