Abstract
A series of 1- and 7-substituted xanthines was studied in vitro for dilator activity in preventing bronchospasm from histamine or acetylcholine.
Two of the most effective, 7-chloroethyl and 7-isoamyl theophylline, were compared to aminophylline in intact guinea pigs exposed to histamine or metacholine aerosols. The effectiveness of the compounds was very similar toward both the spasmogens. 7-Chloroethyl theophylline was the most potent compound tested, by both in vitro and in vivo tests.
Footnotes
- Received June 29, 1956.
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