Abstract
A new nerve-muscle preparation from the urinay bladder of the rabiit is described. Never stimulation in this preparation is purely postganglionie.
It was possible to accomplish an initial block with concentrations of atropine as low as 0.002 microgm./ml. However, a portion of the response (20 to 50 per cent) remained even after large doses.
The following evidence suggested that at least a portion of the response of the nerve-bladder strip is cholinergic: (a) initial block can be accomplished with low doses of atropine; (b) eserine potentiates the response to submaximal stimuli; (c) a partial block by atropimme can be reversed by eserine.
The rate at which atropine blocked the response to acetylcholine was much greater thaim the rate at which it blocked the response to nerve stimulation. This was also true of the rates of recovery.
A non-cholinergic initial contractile phase of the response of the urinary bladder of the dog to pelvic nerve stimulation could not he demomistrated. Atropine was capable of partially blocking this response.
Footnotes
- Received June 14, 1956.
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