Abstract
Employing the Brodie methyl orange and the Craig countercurrent techniques it was shown that meperidine is hydrolyzed and excreted in the urine of man as meperidinic acid and its corresponding acid conjugate. In addition, meperidine is demethylated to normeperidine which is then hydrolyzed to normeperidinic acid and partially conjugated.
Footnotes
- Received March 27, 1956.